As pet allergies and immune concerns rise, many dog owners turn to supplements and medications for relief. This guide lists the 10 most reviewed allergy and immune support products, summarizing key features, pros, cons, and prices. Covering both vet-prescribed and natural options, it helps you choose the best fit for your dog’s needs.

1. Purina Pro Plan Veterinary Diets FortiFlora Probiotic Supplement

FortiFlora by Purina Pro Plan is a vet-recommended probiotic that supports digestive health and immune function in dogs. It contains Enterococcus faecium to help balance gut microflora.

Ideal for dogs with diarrhea, digestive upset, or stress, it’s easy to sprinkle over food and highly palatable. FortiFlora is especially useful during antibiotic use, dietary changes, or travel-related stress.

Pros:

• Proven probiotic strain
• Easy to administer
• Enhances GI health
• Boosts immunity
• Vet-trusted

Cons:

• Pricey
• Requires daily use
• Not allergy-specific
• Single-strain formula
• Some dogs show no change

Price: $30.99

2. PetHonesty Allergy Support Salmon-Flavored Soft Chews

PetHonesty Allergy Support soft chews help manage seasonal and environmental allergies in dogs. They’re made with natural ingredients like colostrum, turmeric, and salmon oil.

These tasty, grain-free chews support immune function and reduce itching and irritation. Added probiotics promote gut health, which can benefit allergy-prone dogs. Free from artificial preservatives and GMOs, they offer daily, holistic allergy support.

Pros:

• Natural ingredients
• Palatable flavor
• Skin & coat support
• Immune boost
• Grain-free

Cons:

• Gradual results
• Crumbly texture
• Not for fish-allergic dogs
• Possible soft stool
• Varies by dog

Price: $84.12

3. Zesty Paws Allergy Immune Bites

Zesty Paws Allergy Immune Bites are lamb-flavored soft chews formulated to support dogs with allergies. They help regulate immune responses and promote healthy skin.

Key ingredients like colostrum, Epicor, and apple cider vinegar work alongside probiotics for digestive support. Free from artificial preservatives, these chews are suitable for all breeds and sizes, helping reduce itching, sneezing, and hot spots with daily use.

Pros:

• Immune-regulating blend
• Digestive support
• Lamb-flavored
• No artificial preservatives
• Suitable for all sizes

Cons:

• Inconsistent results
• Taste may not appeal
• Pricey
• May harden over time
• Daily use required

Price: $58.02

4. StrellaLab Anti-Itch Allergy Relief Dog Chews

StrellaLab Anti-Itch Allergy Relief Chews are soft chews that help relieve itching, hot spots, and inflammation caused by allergies in dogs. They support skin and immune health.

Made with omega-3s, turmeric, pumpkin, and digestive enzymes, this daily, non-drowsy formula promotes gut balance. Free from artificial colors or preservatives, the chicken-flavored chews offer a natural, plant-based solution for dogs with mild to moderate allergy symptoms.

Pros:

• Natural ingredients
• Soothes itching
• Skin & coat support
• Digestive aid
• Non-drowsy

Cons:

• May not help severe cases
• Variable texture
• Mixed taste reviews
• Limited research
• Mild GI upset possible

Price: $21.95

5. Nutri-Vet Pre and Probiotic Soft Chews for Dogs

Nutri-Vet Pre and Probiotic Soft Chews support digestive health and wellness in dogs, especially during stress, diet changes, or antibiotic use. Liver-flavored for easy feeding.

Each chew contains prebiotics and five probiotic strains to maintain gut balance and aid nutrient absorption. Made in the USA, they help dogs with sensitive stomachs and may ease some allergy-related symptoms by improving digestive and immune function.

Pros:

• Supports digestion
• Five probiotic strains
• Tasty liver flavor
• Affordable
• Immune boost

Cons:

• Not allergy-targeted
• May dry out
• Some dogs uninterested
• Mild effects
• Large dogs need more

Price: $15.29

6. Finn Allergy & Itch Supplement – Beef Liver Flavor

Finn Allergy & Itch Supplement is a daily chewable tablet that helps soothe itching, paw licking, and skin irritation in dogs with seasonal allergies.

Formulated with bee propolis, quercetin, bromelain, and wild Alaskan salmon oil, it supports skin health and immune balance. Made in the USA with human-grade, non-GMO ingredients, and a tasty beef liver flavor most dogs enjoy.

Pros:

• Anti-inflammatory blend
• Human-grade quality
• Beef liver flavor
• Skin & coat support
• Non-GMO

Cons:

• Pricier option
• Varying effectiveness
• Larger size chew
• May need long-term use
• Mild GI upset possible

Price: $34.00

7. Native Pet Allergy Chews – Daily All-In-One Powder

Native Pet Allergy Chews are a daily powder supplement that supports dogs with allergy sensitivities by targeting immune, skin, and gut health.

Vet-formulated with spirulina, colostrum, and postbiotics, it helps ease itching and irritation. Grain-free and filler-free, the limited-ingredient formula mixes easily with food—ideal for dogs that avoid tablets or chews. Designed for consistent use, it offers a natural, holistic approach to allergy relief.

Pros:

• Holistic ingredients
• Easy to mix
• Gut & skin support
• No fillers
• Vet-formulated

Cons:

• Powder texture
• Not travel-friendly
• Takes time to work
• Can clump in food
• Some dogs dislike taste

Price: $13.99

8. Greenies Hip & Joint Support Supplements

Greenies Hip & Joint Support Supplements are soft chews designed to support joint health and mobility in dogs.

Formulated with glucosamine, chondroitin, and antioxidant vitamins, they help maintain cartilage while also boosting immune function. With a tasty chicken flavor and low-calorie content, these chews are ideal for daily use, offering a convenient dual-action supplement that supports both movement and overall wellness.

Pros:

• Joint & immune support
• Tasty treat format
• Low calorie
• Easy dosing
• Recognized brand

Cons:

• Not allergy-specific
• Mild immune benefits
• Artificial flavors
• Limited size options
• Lower probiotic content

Price: $14.29

9. Grizzly Omega Health Omega-3s Supplement for Dogs

Grizzly Omega Health is a liquid supplement made from wild-caught Alaskan fish, rich in EPA and DHA omega-3s.

It supports healthy skin, coat, joints, heart, and immune function, making it ideal for dogs with allergies or inflammation. Delivered via a convenient pump bottle, it’s easy to add to meals. With no artificial additives and high bioavailability, it’s a gentle, effective daily boost for overall canine wellness.

Pros:

• Rich in omega-3s
• Reduces inflammation
• Easy to dispense
• No additives
• Supports skin & coat

Cons:

• Fishy odor
• Needs refrigeration
• Pump may clog
• Not allergy-specific
• Can stain surfaces

Price: $25.40

10. The Honest Kitchen Daily Boosters Instant Goat’s Milk with Probiotics

The Honest Kitchen Daily Boosters Instant Goat’s Milk supports digestive and immune health in dogs. Made from dehydrated goat’s milk and enriched with probiotics, it’s perfect for sensitive stomachs or recovery.

This powder rehydrates quickly into a warm drink or can be poured over kibble. Free from artificial ingredients, preservatives, and fillers, it may help ease mild digestive upset or food sensitivities.

Pros:

• Digestive support
• Gentle on stomach
• Human-grade
• Easy prep
• Natural ingredients

Cons:

• Short shelf life
• Not allergy-targeted
• Needs mixing
• Some dogs refuse taste
• Small quantity

Price: $16.16